The drug, under development by LOXO Oncology, inhibits tropomyosin receptor kinase, or TRK, and surprised researchers by stopping the progression of cancer in six patients with TRK fusion cancer in different parts of their bodies, researchers said during a presentation at the American Association for Cancer Research’s annual meeting. Early data was presented at another conference last year showing similar efficacy of the drug. The new presentation includes updated information on six TRK fusion patients, five of whom responded to the drug while the sixth showed more significant progress. The researchers were surprised that all patients in the study with TRK gene fusions responded to the drug, though they said their results underscore the importance of genomic testing. For the trial, which is still ongoing, researchers recruited 43 patients with a median age of 57 and advanced cancer, treating them with one of five dose levels. Of the 43 participants, six had a type of cancer with a TRK fusion — sarcoma, thyroid, salivary gland, gastrointestinal and non-small cell lung — with a confirmed response to the drug. A seventh patient also showed regression, though the patient is at an earlier point in the study and has not yet met measurements considered a response. A phase 2 trial is expected to start toward the end of , with enrollment expected to start in the second half of the year, according to the drug’s manufacturer. Josh Bilenker, chief executive officer of Loxo Oncology, said in a press release.
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